In my last two posts on this topic, I provided the history of the development of a mechanical CPR device. I also discussed a recent study examining a very large patient population and comparing survival with and without this device. The punchline was that it did not improve 30-day hospital survival or meaningful neurologic survival when used. Today I’ll look at a few randomized controlled studies and then finish with a Cochrane review on the topic.
The first paper I’ll discuss is the PARAMEDIC trial published in 2014. This study was conducted in non-traumatic arrests in the UK, where ambulance service vehicles were randomly assigned to use a mechanical CPR device versus regular CPR. This intent-to-treat study used 30-day survival as its primary outcome.
A total of 4,471 patients were enrolled with a 1:2 ratio between the mechanical and manual CPR groups. Survival was 6% in the mechanical CPR group and 7% in the manual CPR group. There was no statistically significant difference. There were no serious adverse events in the manual CPR group, but some events did occur in the mechanical group, including chest bruising, lacerations, and blood in the mouth. Mechanical CPR did not confer a survival advantage in this study.
The next study was the LINC randomized trial published in JAMA, also in 2014. It was a multi-center randomized clinical trial of patients suffering from out-of-hospital cardiac arrest in ambulance services in several European countries. The mechanical CPR recipients also underwent defibrillation if appropriate. The authors measured four-hour survival, survival up to six months, and good neurological outcome.
Four-hour survival was 24% in patients with mechanical CPR and 24% in patients with manual CPR. Survival at 6 months with good neurological outcome was 8.5% vs 7.6%, respectively. Looking at the patients who survived for six months from the flip side, good neurologic outcome was present in 99% of the mechanical CPR group and 94% of the manual group. None of these results were statistically significant. Again, there was no significant improvement in clinical outcomes with the mechanical CPR device.
Finally, the Cochrane group reviewed eleven existing studies in 2018. They included nearly 13,000 adult patients who suffered either an out-of-hospital or an in-hospital cardiac arrest. Trauma patients were excluded. The overall quality of the studies was judged to be moderate to low due to the considerable risk of bias.
This review concluded that the evidence does not suggest that mechanical CPR devices are superior to conventional therapy. Some of the data reviewed indicate that there may be an increased risk of harm from using this device.
Bottom line: So what does all this mean? Overall, the idea that using a mechanical device to provide continuous, high-quality CPR to improve patient outcomes doesn’t really hold true. Good, old-fashioned manual CPR does just as well. And the mechanical units sold today retail for about $20,000 each. Are they worth the money?
The answer is… maybe. When continuous manual CPR is difficult because few pre-hospital providers are available in the field, automating CPR can be very handy. In some circumstances, such as hypothermia, CPR may need to be continued for an extended period of time. This will burn through numerous humans in a relatively short period of time. It can also be helpful when patients must be moved between different hospital areas or while preparing to place a patient on cardiac bypass.
Each organization that purchases these units needs to carefully consider how they will use them and how they fit with the resources they have available. Only then can they do the appropriate cost-benefit analysis to see whether it makes sense, given that it seems to have no impact on survival or neurologic outcome.
And when it comes to CPR in trauma patients, things become very hazy. Major trauma patients are either dying from a fatal brain injury or they are bleeding to death. The use of manual or mechanical CPR has no impact on either of these.
References:
- Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial. Lancet. 2015 Mar 14;385(9972):947-55. doi: 10.1016/S0140-6736(14)61886-9. Epub 2014 Nov 16. PMID: 25467566.
- Mechanical Chest Compressions and Simultaneous Defibrillation vs Conventional Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: The LINC Randomized Trial. JAMA. 2014;311(1):53–61. doi:10.1001/jama.2013.282538.
- Mechanical versus manual chest compressions for cardiac arrest. Cochrane Database Syst Rev. 2018 Aug 20;8(8):CD007260. doi: 10.1002/14651858.CD007260.pub4. PMID: 30125048; PMCID: PMC6953326.



