I’ve seen hospitals (and trauma programs) boast that their venous thromboembolism (VTE) rate is very low. The numbers they report to state agencies or TQIP may be fractions of a percent. But is it real?
The main problem is a phenomenon called surveillance bias. This occurs when a condition appears more common in one group because that group is scrutinized more closely, is tested more often, or is screened more aggressively.
For those of you who are old enough to have read House of God by Samuel Shem (1978), there were 13 laws. Law 10 was: if you don’t take a temperature, you can’t find a fever. Similarly, if you rely solely on clinical signs and symptoms to diagnose VTE, you won’t detect it in most cases.

But how big is the difference, anyway? Several recent papers compared them, and of course, the numbers vary widely:
- In a prospective, randomized study of 3,236 patients, surveilled patients had 12.5% below-knee and 1.9% above-knee VTE, vs 0.8% and 0.8% in unscreened patients. The pulmonary embolism (PE) rate was 0.1% among screened patients vs 0.9% in the unscreened, possibly because screened patients were more likely to receive treatment
- In another prospective study, patients screened as high-risk using Greenfield criteria were studied based on their screening status. Although not randomly assigned, 11.6% of 259 screened patients had VTE, compared with 2.1% of 143 patients who were not screened. PE rate was 1.9% in screened patients vs 7.0% in unscreened patients.
- Over 5,000 retrospectively reviewed patients were compared for VTE based on whether they were screened or not (not randomized). A total of 7% of screened patients were found to have VTE, and only 0.06% of unscreened patients had it.
But I think you get the idea. If you look for it, you will find it. If you are not looking, you may be missing a clinically significant finding that could result in significant complications.
Bottom line: trauma patients, and especially the more severely injured ones, are at significant risk for developing VTE. The data show us that looking for clinical signs and symptoms is not very accurate. Reference 4 shows that even one of the common risk assessment tools, the Risk Assessment Profile (RAP), is not very accurate in these patients. Don’t be complacent just because your unscreened VTE rates look good. If you don’t look, you won’t find it. If you don’t screen, the studies listed above tell us that you should probably multiply your unscreened rate by about 5x to get a glimpse of what your real number is. I strongly suggest you incorporate VTE screening into your VTE practice guidelines.
References:
- Trauma patients at risk for venous thromboembolism who undergo routine duplex ultrasound screening experience fewer pulmonary emboli: A prospective randomized trial. J Trauma Acute Care Surg. 2021 May 1;90(5):787-796. doi: 10.1097/TA.0000000000003104. PMID: 33560104.
- Surveillance and Early Management of Deep Vein Thrombosis Decreases Rate of Pulmonary Embolism in High-Risk Trauma Patients. J Am Coll Surg. 2016 Jan;222(1):65-72. doi: 10.1016/j.jamcollsurg.2015.10.014. Epub 2015 Nov 4. PMID: 26616034.
- The Utility of Lower Extremity Screening Duplex for the Detection of Deep Vein Thrombosis in Trauma. J Surg Res. 2022 Jan;269:151-157. doi: 10.1016/j.jss.2021.08.010. Epub 2021 Sep 23. PMID: 34563841.
- The Risk Assessment Profile is suboptimal for guiding duplex ultrasound surveillance in trauma patients. Surg Pract Sci. 2022 Sep 6;11:100127. doi: 10.1016/j.sipas.2022.100127. PMID: 39845166; PMCID: PMC11750042.
