Tag Archives: spleen

Incidental Finding: Gas In The Spleen After Embolization

Most solid organ injury practice guidelines include angioembolization in part of the pathway. But very few require re-imaging at any point to see how the liver or spleen are coming along.

But every once in a while another condition arises, or symptoms worsen unexpectedly, causing us to get another CT scan that includes the abdomen and pelvis. And sometimes we see things that we wouldn’t normally see, like air bubbles in the organ that was embolized.

So what is okay, and what requires some kind of intervention? Our friends at ShockTrauma in Baltimore looked at this in 2001 and can provide some pretty good guidance. They reviewed patients who underwent CT scan both before and after embolization over about 2.5 years. They performed the post-embolization scans for specific indications like fevers, elevated WBC count (!), increasing abdominal pain, or an episode of hypotension. A total of 53 patients were studied.

Here are the factoids:

  • 24 patients underwent embolization of the main splenic artery, 22 had selective embolization of part of the spleen, and 7 had both
  • Splenic infarcts occurred in 63% of patients with main artery embolization, but were large (> 50% of the parenchyma) in only 20% of those
  • Infarcts occurred in 100% of selective embolizations, but were small (< 50%) in 93% of cases
  • Infarcts occurred in 71% of patients with both main and selective embolization, and most were small (80%)
  • Seven (13%) patients developed gas bubbles in the spleen, and was usually present for 1-7 days before disappearing
  • One patient developed increasing gas with pneumoperitoneum and underwent splenectomy for a splenectomy for abscess

This picture that shows tiny bubbles in the spleen parenchyma that represent “normal” gas after embolization:

And the following one shows an air/fluid collection in the spleen that indicates an abscess:

Bottom line: Tiny bubbles in the spleen (and probably the liver) occur normally after angioembolization. They usually develop within an area of infarction, and most are benign. It is possible for them to evolve into a splenic abscess, but unlikely. Many embolization patients develop fevers at some point, and most have an elevated WBC count. So in most cases, you can ignore this incidental finding, as long as your patient has mild symptoms.

However, if the patient develops high fevers, very elevated WBC (> 25K), increasing abdominal or flank pain, and the spleen develops an air/fluid level, an abscess is forming. Despite what your radiologist might suggest, catheter drainage is not a good idea. The tubes are too small to remove the slurry that is generally found within the abscess. A trip to the OR is the only effective treatment, and splenectomy is generally the only option.

Related posts:

Reference: CT Findings after Embolization for Blunt Splenic Trauma. J Vasc Intervent Radiol 12(2):209-214, 2001.

EAST 2017 #12: Revaccination Compliance After Splenectomy

The incidence of overwhelming post-splenectomy sepsis, and the need and effectiveness for vaccination after splenectomy is still subject to debate. However, the administration of three vaccines to protect against encapsulated bacteria is a standard of care. For decades, this was a one time thing and the vaccines were usually given before the spelenctomized trauma patient was discharged from the hospital.

Then several years ago, the CDC updated their recommendations to include a booster dose of 23-valent penumococcal vaccine. Trauma professionals have inconsistently advised their patients about this dose, and patients have not reliably sought their booster.

Researchers at Christiana Care in Delaware looked at this potential problem by identifying all of their trauma splenectomy patients over a 10 year period. They were interviewed by phone to determine their understanding of the asplenic state and the need for booster vaccination.

Here are the factoids:

  • During the 10 year period, 267 trauma splenectomies were performed
  • 196 survived, but only 52 agreed to participate (? – see below)
  • Although all patients received vaccines before discharge (!), only 23% were aware that they had
  • Only about half of patients were aware that they may be at risk for infectious complications
  • Only 19% understood they would require a booster dose, and 22% had actually received one (?? – see below)

Bottom line: Although we still aren’t sure how important these vaccines are, vaccination is the standard of care. This study, although a little confusing, shows that we are falling down in educating our patients about the impact of their splenectomy (surgical or via embolization). And it’s difficult for anyone to remember to get a booster shot. Are you up to date on your tetanus vaccination?

This abstract shows us that we need to counsel these patients prior to discharge regarding their at-risk condition. We also need to make sure they (and their primary care provider) are aware that they need to get a pneumococcal booster five years down the road.

News flash! Take a look at page 3 of the CDC recommendations (download here) to see the official recommendations regarding pneumococcal vaccination. It is recommended that PCV-13 vaccine (Prevnar 13) be given first, then the 23-valent vaccine (Pneumovax) 8 weeks later! This complicates things a bit, since both pneumococcal vaccines cannot be given while the patient is still in the hospital. This will reduce the likelihood that patients will get their second pneumococcal vaccine.

Questions and comments for the authors/presenters:

  1. The number of patients is off by one. There were 267 splenectomy patients, 49 died in the hospital and 23 after discharge. 267-49-23=195, not 196.
  2. Only 52 of this 195 agreed to participate. You were able to find all 195? It seems that some of these 143 patients just could not be located.
  3. Please clarify the numbers in my last bullet point. Of the 52 patients, only 9 were aware of the revaccination requirement, and only 1 got it?
  4. This is important work. What have you done to improve these numbers at your hospital?

Click here to go the the EAST 2017 page to see comments on other abstracts.

Related posts:

Reference: Revaccination compliance after trauma splenectomy: a call for improvement. Poster #31, EAST 2017.

Early Mobilization In Solid Organ Injury

Most trauma centers have some kind of practice guideline for managing solid organ injury. Unfortunately, the specifics at each center are all over the map. Here are a few common questions:

  • Should you keep the patient NPO?
  • How often should Hgb/Hct be repeated?
  • Should they be at bed rest?
  • What are their activity restrictions after they go home?

spleen-lac

As for activity, some earlier studies have shown that early ambulation is safe. The group at Hahnemann University Hospital in Philadelphia tried to determine if early mobilization would decrease time in ICU and/or the hospital, or increase complications.

Until 2011, their trauma service kept all patients with solid organ injury at bed rest for 3 days(!). They modified this routine to allow ambulation the following morning for Grade 1 and 2 injuries, and after 24 hours for Grade 3 and above, or those with hemoperitoneum. They examined their experience for 4 years prior (PRE) and 4 years after (POST) this change. They excluded patients with penetrating injury, or other significant injuries that would impact the length of stay.

Here are the factoids:

  • 300 solid organ injury patients were identified in the PRE period, and all but 89 were excluded
  • 251 were identified in the POST period, and all but 99 were excluded
  • Hospital length of stay was significantly shorter (5.9 vs 3.7 days) after implementation of the new guideline
  • ICU length of stay also decreased significantly, from 4.6 to 1.8 days
  • The authors extrapolated a cost savings of about $40K for the ICU stay, and $10K for the ward stay, per patient
  • There was one treatment failure in each group

Bottom line: It’s about time we recognized what a waste of time these restrictions are! Unfortunately, the study groups became very small after exclusions, but apparently the statistics were still valid. But still, it continues to become clear that there is no magic in keeping someone starving in their bed for any period of time.

At my hospital, we adopted a practice guideline very similar to this one way back in 2004 (download it below). Hospital lengths of stay dropped to about 1.5 days for low grade injury, and to about 2.5 days for high grade.

And earlier this year, we eliminated the NPO and bed rest restrictions altogether! How many patients actually fail and end up going urgently to the OR? So why starve them all? And normal activity started immediately is no different than activity started a few hours or days later.

Don’t starve or hobble your patients, adults or children!

Related posts:

Reference: Early mobilization of patients with non-operative liver and spleen injuries is safe and cost effective. AAST 2016, Poster #5.

Spleen Injury, Angiography, And Splenectomy

The shift toward initial nonoperative management of spleen injuries began in the early 1990’s, as the resolution of early CT scans began to improve. Our understanding of the indicators of failure also improved over time, and success rates rose and splenectomy rates fell.

Angiography was adopted as an adjunct to early management, especially when we figured out what contrast extravasation and pseudoaneurysms really meant (bad news, and nearly certain failure in adults). At first, it was used in a shotgun approach in most of the higher grade injuries. But we have refined it over the years, and now it is used far more selectively at most centers.

A group at Indiana University was interested in looking at the impact of angio use on splenic salvage over a long time frame. They queried the National Trauma Data Bank, looking specifically at high grade splenic injury care at Level I and II centers from 2008-2014. Patients undergoing splenectomy were divided into early (<= 6hr after admission) and late (> 6 hrs). Over 50,000 records were analyzed.

Here are the factoids:

  • There was a shift from early splenectomy to late splenectomy over the study period that was statistically significant
  • Use of angio increased from 5 to 12% during the study period
  • Overall splenectomy rate remained about the same

So the authors recognize that late splenectomy has decreased. But they also state that early splenectomy has increased. They attribute it to increased recognition of patient requiring early splenectomy. They then call into question the need to use angiography if it hasn’t decreased the overall splenectomy rate.

Problem: The early splenectomy rate increased from about 13% to 14%, reading their graph, and is probably not significant. These are the failures that occur in the trauma bay and shortly thereafter that must be taken to the OR. The late splenectomy rate decreased from 5% to 3%, which may be significant (p value not included in the abstract). These are failures during nonoperative management, and are decreasing over time. And BTW, the authors do not define what “high grade” splenic injuries they are looking at.

AAST2016-Paper35

Bottom line: This abstract illustrates why it is important to read the entire article, or in this case, listen to the full presentation at AAST. It sounds like one that’s been written to justify not having angiography available as it is currently required. 

The authors showed that overall splenectomy rate was the same, but delayed splenectomy (late failure) has decreased with increasing use of angiography. But remember, this is an association, not cause and effect. Most of the early failures are still probably ones that can’t be prevented, but we’ll see if the authors can dissect out how many went to OR very early (not eligible for angio), or later in the 6 hour period (could have used angio). It looks to me like the use of angiography is having the desired effect. But undoubtedly we could use that resource more wisely. What we really need are some guidelines as to exactly when a call to the interventional radiologists is warranted.

Related posts:

Reference: Overall splenectomy rates remain the same despite increasing usage of angiography in the management of high grade blunt splenic injury. AAST 2016, paper 35.