For as long as I can remember (nearly 50 years worth of literature) there has been some debate about giving antibiotics after chest tube insertion to decrease the infection rate. The pendulum moved back and forth for decades, never getting very far into the “give antibiotics” side. It’s been quite a while since I remember any new papers on this, and I thought the debate had been resolved in favor of never using them.
But then I see an abstract from the AAST multi-institutional trials group studying presumptive antibiotics after chest tube insertion! They conducted a prospective, observational study at 22 Level I trauma centers, enrolling nearly 2,000 patients. They matched patients in antibiotic and no antibiotic groups, arriving at (only) 272 patients in each group.
Here are the results:
Bottom line: First, it’s a little disappointing that the numbers were so low with a trial that includes 22 trauma centers. Did they have a hard time finding centers that would give antibiotics? Or was it just hard to match patients for the variables they were looking at? Regardless, there were no significant differences in infectious complications, and a non-clinically significant difference in ICU stay with antibiotics.
Why won’t this die? If there are so few papers that show an actual benefit from giving antibiotics after chest tube insertion with 50 years of data, then it’s very unlikely that it will ever be shown to be necessary!
Reference: Presumptive antibiotics for tube thoracostomy for traumatic pneumothorax. Session XXII Paper 49, AAST 2018.