Tag Archives: pediatric trauma

Abstracts

Best of EAST 2024 #3: VTE Prophylaxis For Pediatric Trauma

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Venous thromboembolism (VTE) after trauma in adults has generated a considerable body of literature for guidance. However, there is much less information available regarding pediatric trauma. High-risk criteria for pediatric VTE after trauma have recently been released.

These criteria have not yet been evaluated prospectively or coupled with the administration of chemoprophylaxis. The Medical College of Wisconsin trauma group organized a prospective, multi-institutional study involving eight pediatric trauma centers. They studied VTE events within 30 days and bleeding complications. The children were stratified into three groups: no prophylaxis, early prophylaxis (within 24 hours), and late prophylaxis.

Here are the factoids:

  • A total of 460 patients were enrolled during a three-year period
  • The number of VTE events was very low at 25 (5.4%)
  • Patients who developed VTE had a median of 4 of the high-risk criteria, most commonly ICU stay>48 hours and TBI.
  • Half of patients received prophylaxis
  • VTE occurred in 1.6% receiving an early dose and 6.7% with late dosing
  • There were no bleeding complications

The authors concluded that prophylaxis in children at high risk for VTE was safe, but they could not demonstrate any risk reduction for those who had received chemoprophylaxis compared to those who had not.

Bottom line: This is another study that was cursed by low numbers. See the breakdown chart below:

There is a trend toward higher VTE in children receiving prophylaxis late or never. However, the number of subjects is far too low to detect significance. The good news is that there were no bleeding events in this modest sample of 257 patients. 

So what next? The authors state that “further subgroup analysis is ongoing to refine the high-risk criteria.” Good luck with that because subgrouping will deplete the numbers even further.

There are several things the authors could do to improve this work:

  • Get more subjects! Increase the number of centers participating, and consider sending it through the EAST Multicenter Trial process.
  • Streamline the list of high-risk criteria. There are quite a few of them. Try to focus on the most obvious ones and make sure each one has clear definitions. And set a threshold of how many must be present to trigger chemoprophylaxis.
  • Define the pediatric patient precisely. As children approach puberty, they behave more like adults as it pertains to VTE. State an explicit age cutoff.

This presentation should be a springboard to soliciting help from other pediatric trauma centers so this group can return to this meeting with compelling information.

Reference: The No Clot VTE study in high-risk pediatric trauma patients. EAST 2024 Podium paper #6.

Imaging

Maxillofacial CT Scans In Children

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Facial trauma is common, especially in children. And the use of CT scan is even more common, unfortunately for children. What happens when these two events meet?

I’ve noted that many trauma professionals almost reflexively order a face CT when they see any evidence of facial trauma. This ranges from obvious deformity to lacerations to mere contusions. This seems like overkill to me, since most of the face (excluding the mandible) is visualized with the head CT that nearly always accompanies it.

Finally, someone has actually examined the usefulness of the facial CT scan! The trauma group at Albany collaborated with four other Level I trauma centers, performing a retrospective chart and database review of children (defined as less than 18 years old) who underwent both head and maxillofacial CT scans over a five year period. They excluded penetrating injuries and bites. The concordance of facial fractures seen on head CT vs face CT was evaluated.

Here are the factoids:

  • A total of 322 patients with facial fractures was identified, and the most common mechanisms were MVC, pedestrian struck, and bicycle crash
  • Fractures on head CT matched the facial CT in 89% of cases
  • Of the 35 discordant cases, 21 of the head CTs missed nasal fractures, 9 mandibular fractures, 3 orbital fractures, and 2 maxillary fractures
  • Of those 35 cases, only 7 required operative intervention: 6 mandible fractures and 1 maxillary fracture

The authors concluded that the use of head CT alone with a good clinical exam detects nearly all facial fractures requiring repair.

Bottom line: Although this study confirms my own personal bias and experience, it suffers from the usual problems associated with retrospective studies and small numbers. Nonetheless, the results are compelling. This study provides a way to identify nearly all significant fractures while minimizing radiation to the ocular lens, thyroid, and bone marrow.

The key is a good physical exam, as usual. Inspection of the teeth, occlusion testing, and manipulation of the mandible and maxilla should identify nearly all fractures that might require operation.

Once the exam is complete, a standard head CT should be obtained. Identification of displaced fractures on the head CT should prompt a consult to your friendly facial surgeon to see if they really need additional imaging to determine if the fracture requires operation. Frequently, the head CT images are sufficient and nothing further is required.

Here is the algorithm the authors recommend. Although designed for children, it should work for adults just as well.

Reference: Clinical and radiographic predictors of the need for facial CT in pediatric blunt trauma: a multi-institutional study. Trauma Surg Acute Care Open 2022;7:e000899.

Resuscitation

Blunt Traumatic Arrest In Kids: Are They Little Adults?

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Over and over, we hear that children are not just little adults. They are a different size, a different shape. Their “normal” vital signs are weird. Drug doses are different; some drugs don’t work, some work all too well.

But in many ways, they recover more quickly and more completely after injury. What about after what is probably the biggest insult of all, cardiac arrest after blunt trauma? The NAEMSP and the ACS Committee on Trauma previously released a statement regarding blunt traumatic arrest (BTA):

 “Resuscitation efforts may be withheld in any blunt trauma patient who, based on out-of-hospital personnel’s thorough primary patient assessment, is found apneic, pulseless, and without organized ECG activity upon arrival of EMS at the scene.“

The groups specifically point out that the guidelines do not apply to the pediatric population due to the scarcity of data for this age group.

The Children’s Hospital of Los Angeles and USC conducted a study of the National Trauma Data Bank, trying to see if children had a better outcome after this catastrophic event. Patients were considered as children if they were up to and including age 18.

Here are the factoids:

  • Of 116,000 pediatric patients with blunt trauma, 7,766 had no signs of life (SOL) in the field (0.25%)
  • The typical male:female distribution for trauma was found (70:30)
  • 75% of those without SOL in the field never regained them. Only 1.5% of these survived to discharge from the hospital.
  • 25% regained SOL with resuscitation, and 14% of them were discharged alive.
  • 499 patients underwent ED thoracotomy, and only 1% survived to discharge. There was no correlation of thoracotomy with survival.
  • It appeared that there was a tendency toward survival for the very young (age 0-4) without SOL, but statistical analysis did not bear this out

Bottom line: Children are just like little adults when it comes to blunt cardiac arrest after trauma. Although it is a retrospective, registry-based study, this is about as big as we are likely to see. And don’t get suckered into saying “but 1.5% with no vital signs ever were discharged!” This study was not able to look at the quality of life of survivors, but there is usually significant and severe disability present in the few adult survivors after this event.

Feel free to try to re-establish signs of life in kids with BTA. This usually means lots of fluid and/or blood. If they don’t respond, then it’s game over. And, like adults, don’t even think about an emergency thoracotomy; it’s dangerous to you and doesn’t work!

Reference: Survival of pediatric blunt trauma patients presenting with no signs of life in the field. J Trauma 77(3):422-426, 2014.

Complications

How To Predict Venous Thromboembolism In Pediatric Trauma

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As with adults a decade ago, the incidence of venous thromboembolism (VTE) in children is now on the rise. Whereas adult VTE occurs in more than 20% of adult trauma patients without appropriate prophylaxis, it is only about 1% in kids, but increasing. There was a big push in the early 2000′s to develop screening criteria and appropriate methods to prevent VTE. But since the incidence in children was so low, there was no impetus to do the same for children.

The group at OHSU in Portland worked with a number of other US trauma centers, and created some logistic regression equations based on a large dataset from the NTDB. The authors developed and tested 5 different models, each more complex than the last. They ultimately selected a model that provided the best fit with the fewest number of variables.

The tool consists of a list of risk factors, each with an assigned point value. The total point value is then identified on a chart of the regression equation, which shows the risk of VTE in percent.

Here are the factors:

Note that the highest risk factors are age >= 13, ICU admission, and major surgery.

And here is the regression chart:

Bottom line: This is a nice tool, and it’s time for some clinical validation. So now all we have to do is figure out how much risk is too much, and determine which prophylactic tools to use at what level. The key to making this clinically usable is to have a readily available “VTE Risk Calculator” available at your fingertips to do the grunt work. Hmm, maybe I’ll chat with the authors and help develop one!

Reference: A Clinical Tool for the Prediction of Venous Thromboembolism in Pediatric Trauma Patients. JAMA Surg 151(1):50-57, 2016.

Abdomen, Abstracts

AAST 2019 #3: Delayed Splenectomy In Pediatric Splenic Injury

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Nonoperative management of the blunt injured spleen is now routine in patients who are hemodynamically and have no evidence of other significant intra-abdominal injury.  The trauma group at the University of Arizona – Tucson scrutinized the failure rate of this procedure in children because it is not yet well established.

They reviewed 5 years of data from the National Readmission Database. This is actually a collection of software and databases maintained by the federal government that seeks to provide information on a difficult to track patient group: those readmitted to hospitals after their initial event.

Patients who had sustained an isolated spleen injury who were less than 18 years old and who had either nonoperative management (NOM), angioembolization (AE), or splenectomy were analyzed. Outcome measures included readmission rate, blood transfusion, and delayed splenectomy. Common statistical techniques were used to analyze the data.

Here are the factoids:

  • About 9500 patients were included, with an average age of 14
  • Most (77%) underwent NOM, 16% had splenectomy, and 7% had AE (no combo therapies?)
  • Significantly more patients with high grade injury (4-5) had splenectomy or AE than did the NOM patients (as would be expected)
  • A total of 6% of patients were readmitted within 6 months of their initial injury: 12% of NOM *, 8% of AE *, and 5% of those with splenectomy (* = statistically significant)
  • The NOM and AE patients were also more likely to receive blood transfusions during their first admission
  • Delayed splenectomy occurred in 15% of cases (7% NOM and 5% AE) (these numbers don’t add up, see below)
  • Statistical analysis showed that delayed splenectomy was predicted by high grade injury (of course), blood transfusion (yes), and nonoperative management (huh?)
  • In patients who were readmitted and splenectomized, it occurred after an average of 14 days for the NOM group and 58 days for AE (huh?)

The authors concluded that “one in seven children had failure of conservative management and underwent delayed splenectomy within 6 months of discharge.” They stated that NOM and AE demonstrated only a temporary benefit and that we need to be better about selecting patients for nonoperative management.

Hmm, there are several loose ends here. First, what is the quality of the study group? Was it possible to determine if these patients had been treated in a trauma center? A pediatric vs adult trauma center? We know that there are outcome disparities in spleen trauma care at different types of trauma centers. 

Next, are they really pediatric patients? Probably not, since age < 18 were included and the average age was 14. Injured spleens in pre-pubescent children behave much better than adolescents, which are more adult-like.

And what about the inherent bias in the “readmission data set?” You are looking only at patients who were readmitted! By definition, youare looking at a dataset of poorer outcomes. What if you had identified 9,500 initial patient admissions from trauma registries and then tried to find them in the readmission set. I know it’s not possible to do that, but if it were I would bet the readmission and delayed splenectomy numbers would be far, far lower.

And what about those delayed splenectomy numbers? I can’t get the percentages to match up. If 15% of the 7965 patients who didn’t have an initial splenectomy  had it done later, how does 7.2% of the 7318 NOM patients and 5.3% of the 1541 AE patients add up?

Bottom line: The usual success rate tossed around for well-selected nonoperative management is around 93% when optional adjunctive AE is part of the algorithm. That’s a 1 in 14 failure rate, and it generally occurs during the initial hospitalization. In my experience, readmissions are very rare. And that’s for adults; children tend to behave even better!

I wouldn’t consider changing my practice yet based on these findings, but the devil will probably be in the details!

Here are some questions for the presenter and authors:

  • Please provide some detail on the data set. We really need to know an age breakdown and the types of centers they were treated at, if available.
  • Discuss the potential data set bias working backwards from a database that includes only readmitted patients.
  • Please clarify the delayed splenectomy statistics to help match up the numbers.

I’m anticipating a great presentation at the meeting!

Reference: Delayed splenectomy in pediatric splenic injuries: is conservative management overused? AAST 2019 Oral abstract #8.